Doebner-Miller Reaction and Mechanism

The Doebner–Miller reaction is an organic synthesis method where an aniline reacts with an α,β-unsaturated carbonyl compound under acidic conditions to form substituted quinolines. Also known as the Skraup–Doebner–von Miller reaction, it serves as a foundational route for producing quinoline scaffolds.

Mechanism of Doebner-Miller Reaction

Applications of Doebner-Miller Reaction

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